Laboratory use only.
Not for human consumption.
Stock: Available
3-HO-PCP also known as: 3-Hydroxyphencyclidine is a dissociative of the Arylcyclohexylamine class related to Phencyclidine (PCP)
3-HO-PCP acts as a high-affinity uncompetitive antagonist of the NMDA receptor via the dizocilpine (MK-801) site (Ki = 30 nM).
It has much higher affinity than PCP for this site (Ki = 250 nM, for comparison; 8-fold difference).
The drug also has high affinity for the μ-opioid receptor (MOR) (Ki = 39–60 nM) in animal test subjects,
the κ-opioid receptor (KOR) (Ki = 140 nM), and the sigma σ1 receptor (Ki = 42 nM; IC50 = 19 nM), whereas it has only low affinity for the
δ-opioid receptor (Ki = 2,300 nM).
The high affinity of 3-HO-PCP for opioid receptors is unique among arylcyclohexylamines and is in contrast to PCP,
which has only very low affinity for the MOR (Ki = 11,000–26,000 nM; 282- to 433-fold difference) and the
other opioid receptors (Ki = 4,100 nM for the KOR and 73,000 nM for the DOR).
Although it was hypothesized that 3-HO-PCP might be a metabolite of PCP in humans, there is no evidence that this is the case.
Last stock update: September 2024 - Tags: buy online 2024, Buy 3-HO-PCP
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